A total of 94 newborns with neonatal sepsis who were admitted to the neonatal intensive care unit of Dong-A university hospital for 3 years and a month from October 1992 to October 1995 was tested for the incidence rate of neonatal sepsis, the
isolation
rate of causative microorganisms, the antimicrobial sensitivity of causative microorganisms, and the motality rate of neonatal sepsis, and the results were compared with those of previous neonatal sepsis studies.
@ES The results were summarized as follows;
@EN 1) The incidence rate of neonatal sepsis was 1.7% with male predominancy and more prevalent in premature babies(6.9%) than in full term babies(1.2%).
2) The incidence rate was higher in low birth weight infant below 2,500 g than in normal birth weight infant.
3) It was revealed that gram negative organisms(58.5%) were more frequently isolated than gram positive organisms(30.8%) in blood culture reports, Isolation rate of candida in neonatal sepsis was increasing in recent years.
4) Gram positive organisms were sensitive to vancomycin, teicoplanin and bactrim and gram negative organisms were sensitive to amikacin, imipenem and third generation cephalosporins.
5) Overall mortality rate was 14.9% in all patients with neonatal sepsis.
These results suggested that the causative microorganisms of neonatal sepsis varied for the past years, and effective antibiotics which were particularly sensitive to gram negative bacteria should be chosen, and isolation rate of candida in
neonatal
sepsis was increasing in our study.
In addition, it is necessary to specify the strategic antibiotics which are sensitive to the predominant microorganism in each institute.
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